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Leg swelling, or oedema, is fluid accumulating in the tissues of the leg. The single most useful question in assessing it is whether one leg is swollen or both, because that one distinction separates a local venous or lymphatic problem from a systemic cardiac, renal or hepatic one. Sudden swelling of one leg is a medical emergency until proven otherwise.
Swelling of one leg suggests a local cause: deep vein thrombosis, chronic venous insufficiency, cellulitis, lymphoedema, a ruptured Baker’s cyst or compression of the pelvic veins.
Swelling of both legs suggests a systemic cause: heart failure, kidney disease, liver disease, low blood protein, thyroid disease or a medication side effect.
Sudden painful swelling of one leg, especially with calf tenderness after surgery, immobility or a long flight, must be assessed the same day for deep vein thrombosis, because a clot that travels to the lungs is life-threatening.
1. Venous: Varicose veins and chronic venous insufficiency, where failed valves let blood pool in the leg. This is the commonest cause of chronic bilateral ankle swelling that worsens through the day.
2. Deep vein thrombosis: A clot obstructing the deep venous system.
3. Lymphoedema: Impaired lymphatic drainage, whether congenital, post-surgical, post-radiation or filarial.
4. Cardiac: Right heart failure causing symmetrical pitting oedema with breathlessness.
5. Renal and hepatic: Nephrotic syndrome and cirrhosis, causing low albumin and generalised oedema.
6. Infection: Cellulitis, producing a hot, red, tender, swollen leg with fever.
7. Medication: Calcium channel blockers such as amlodipine, steroids, NSAIDs and some diabetes drugs.
8. Prolonged standing or sitting, pregnancy and obesity.
1. Swelling worse at the end of the day and better after a night’s rest, which is typical of venous disease
2. An indentation that remains when you press the skin (pitting oedema)
3. Tight shoes, sock marks and a heavy, aching sensation
4. Warning signs needing urgent care: sudden onset, one-sided swelling with pain, redness and heat, fever, chest pain or breathlessness
Seek same-day care for sudden swelling of one leg, or any swelling with chest pain or breathlessness. See a vascular specialist for swelling that has persisted for weeks, is associated with visible varicose veins, skin discolouration or ulceration, or is not improving with leg elevation.
1. Establish the cause: Venous Doppler ultrasound, along with blood tests for kidney, liver, cardiac and thyroid function where both legs are involved.
2. Compression therapy: Graduated compression stockings are the foundation of treatment for venous and lymphatic swelling.
3. Treat the underlying venous disease: Endovenous laser ablation or radiofrequency ablation of the refluxing veins. See varicose veins treatment.
4. Anticoagulation: Immediate blood thinners for confirmed deep vein thrombosis.
5. Antibiotics: For cellulitis, with elevation and rest.
6. Manual lymphatic drainage and complex decongestive therapy for lymphoedema.
7. Address systemic causes: Cardiac, renal or hepatic management in coordination with the relevant physician, and reviewing any medication that may be responsible.
Chronic venous swelling does not stay just swelling. Sustained pressure in the tissues causes pigmentation, hardening of the skin and fat (lipodermatosclerosis) and eventually a venous ulcer that can take months to heal and tends to recur. Untreated lymphoedema becomes progressively fibrotic and irreversible. And an untreated deep vein thrombosis carries a real risk of pulmonary embolism. Early identification of the cause is what prevents each of these paths.

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