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Gallstones are solid deposits that form in the gallbladder, most commonly from cholesterol. They are extremely common, and a substantial proportion of people who have them never know it. The clinical question is therefore not simply whether stones are present, but whether they are causing symptoms, because that single distinction determines whether surgery is advised or not.
The gallbladder stores and concentrates bile produced by the liver, releasing it after meals to help digest fat. When bile becomes supersaturated with cholesterol or bilirubin, crystals form and aggregate into stones. Problems arise when a stone intermittently blocks the gallbladder outlet, producing biliary colic, or blocks it completely, producing acute cholecystitis.
The classical risk factors are often summarised as the four Fs: female, forty, fertile and overweight. More completely:
1. Female sex, pregnancy and oestrogen-containing contraceptives
2. Obesity, and also rapid weight loss or crash dieting, which paradoxically increases risk
3. Age over 40
4. Diabetes and metabolic syndrome
5. High cholesterol, high fat and low fibre diet
6. Family history
7. Haemolytic anaemias, which cause pigment stones
8. Prolonged fasting or intravenous nutrition
1. Biliary colic: Severe, steady pain in the right upper abdomen or epigastrium, often radiating to the right shoulder blade, typically starting 1 to 2 hours after a fatty meal and lasting 30 minutes to a few hours.
2. Nausea, vomiting, bloating and fat intolerance
3. Acute cholecystitis: Persistent pain lasting more than 6 hours with fever and marked tenderness
4. Obstructive jaundice: Yellow eyes, dark urine and pale stools if a stone passes into the bile duct
5. Gallstone pancreatitis: Severe upper abdominal pain radiating to the back with vomiting, a serious complication
6. Asymptomatic: Found incidentally on an ultrasound done for another reason
See a surgeon for any episode of biliary colic, since symptoms almost always recur and complications develop from repeated attacks. Seek emergency care for pain lasting more than six hours, fever with chills, yellowing of the eyes, or severe pain radiating to the back with vomiting. Diabetic patients should be assessed promptly, as they develop complications with fewer warning signs.
1. Ultrasound abdomen: The primary investigation, highly accurate for gallbladder stones. MRCP is added if bile duct stones are suspected.
2. Observation: Asymptomatic stones found incidentally generally need no surgery, with some exceptions such as very large stones, a calcified porcelain gallbladder, gallbladder polyps or diabetic patients, where surgery is advised.
3. Laparoscopic cholecystectomy: The definitive treatment for symptomatic gallstones. Keyhole removal of the gallbladder through four small incisions, usually with a one-day hospital stay and return to normal activity within a week.
4. Open cholecystectomy: Reserved for complex cases or severe inflammation.
5. ERCP: Endoscopic removal of stones that have migrated into the common bile duct, usually before or after cholecystectomy.
6. Emergency management: Antibiotics and early surgery for acute cholecystitis, and supportive management for gallstone pancreatitis followed by cholecystectomy.
7. Dietary measures: A low-fat diet reduces attacks while awaiting surgery, but does not dissolve stones.
Once gallstones have caused one episode of pain, the great majority of patients will have further episodes, and each attack carries a risk of something worse. Repeated inflammation makes the gallbladder thick, scarred and adherent, converting what would have been a straightforward keyhole operation into a difficult one with a higher chance of conversion to open surgery and bile duct injury. A stone escaping into the bile duct causes jaundice or pancreatitis, the latter of which can be life-threatening. Long-standing stones are also associated with a small increased risk of gallbladder cancer, which is notably more common in India than in most of the world. Elective surgery after the first attack is considerably safer than emergency surgery later.

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