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Female infertility is the inability to conceive after twelve months of regular unprotected intercourse, or after six months if the woman is over 35. Conception requires several things to align: a released egg, open fallopian tubes, a receptive uterus, adequate hormonal support and sperm reaching the egg. A problem at any one of these points prevents pregnancy, and identifying which point is affected is what makes treatment effective.
1. Ovulation disorders: Polycystic ovary syndrome is the leading cause, along with thyroid dysfunction, high prolactin, and diminished ovarian reserve.
2. Tubal factors: Blocked or damaged fallopian tubes following pelvic inflammatory disease, genital tuberculosis (still an important cause in India), previous ectopic pregnancy or pelvic surgery.
3. Uterine factors: Fibroids distorting the cavity, polyps, intrauterine adhesions (Asherman’s syndrome) and congenital uterine anomalies.
4. Endometriosis: Causing adhesions, distorted anatomy, poor egg quality and painful periods.
5. Cervical factors: Hostile cervical mucus or cervical stenosis after previous procedures.
6. Age: Both egg quantity and quality decline appreciably after 35 and sharply after 38.
7. Lifestyle and metabolic: Obesity, being significantly underweight, smoking, uncontrolled diabetes and chronic stress.
1. Ovulation assessment: Cycle history, mid-luteal progesterone and follicular monitoring by ultrasound.
2. Ovarian reserve testing: AMH and antral follicle count.
3. Hormone profile: FSH, LH, TSH, prolactin and, where PCOS is suspected, androgens and insulin resistance markers.
4. Tubal patency: Hysterosalpingography or sono-salpingography.
5. Uterine assessment: Transvaginal ultrasound, and hysteroscopy where the cavity is suspect.
6. Laparoscopy: Where endometriosis, adhesions or tubal disease is suspected.
7. Male partner evaluation: A semen analysis, done at the same time rather than months later, since a male factor is involved in about half of couples.
Seek evaluation after twelve months of trying, or after six months if you are over 35. Come sooner if you have irregular or absent periods, severe period pain, known PCOS or endometriosis, previous pelvic surgery or infection, recurrent miscarriage, or a history of tuberculosis.
1. Ovulation induction: Letrozole or clomiphene, with gonadotropins where needed, under ultrasound monitoring.
2. Metabolic correction: Weight reduction, insulin sensitisers and exercise, which restore ovulation in a large proportion of women with PCOS.
3. Surgical correction: Hysteroscopic removal of polyps, submucous fibroids or adhesions; laparoscopic treatment of endometriosis and tubal disease.
4. Treating the underlying condition: Thyroid and prolactin correction, and anti-tubercular therapy where genital tuberculosis is confirmed.
5. Assisted reproduction: IUI for mild factors and unexplained infertility, IVF or ICSI for tubal blockage, severe endometriosis, low ovarian reserve or failed simpler treatments.
6. Couple-centred care: Counselling and support, since the emotional burden of infertility treatment is substantial and affects adherence.
Female fertility is time-sensitive in a way that few other medical conditions are. Ovarian reserve declines steadily and irreversibly, and success rates for every treatment, including IVF, fall year on year after 35. Untreated endometriosis progresses and causes further adhesions, and an untreated tubal infection can convert a repairable tube into one that must be bypassed with IVF. Starting evaluation early does not commit you to aggressive treatment; it simply preserves the range of options while they are still open.

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