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Infertility is defined as the failure to conceive after twelve months of regular unprotected intercourse. A male factor is solely or partly responsible in roughly half of all couples, yet in practice the woman is usually investigated first and far more extensively. This is both unfair and inefficient, because the basic male evaluation is simpler, cheaper and faster than the female one.
Male fertility depends on three things working together: producing enough healthy sperm, transporting them through an open ductal system, and delivering them effectively during intercourse. A problem at any of these three levels causes infertility. Importantly, many men with significantly abnormal semen parameters have completely normal sexual function and no symptoms at all, which is why a semen analysis is essential rather than optional.
1. Varicocele: The single most common correctable cause, found in a large proportion of infertile men.
2. Hormonal: Low testosterone, high prolactin, thyroid disease and pituitary disorders.
3. Infection: Epididymo-orchitis, mumps orchitis in adolescence, tuberculosis and sexually transmitted infections causing ductal blockage.
4. Obstruction: Congenital absence of the vas deferens, post-surgical or post-infective blockage, and previous vasectomy.
5. Genetic: Klinefelter syndrome and Y-chromosome microdeletions.
6. Lifestyle and environmental: Smoking, alcohol, obesity, heat exposure, anabolic steroid use, chemotherapy, radiation and pesticide exposure.
7. Sexual and ejaculatory: Erectile dysfunction, severe premature ejaculation and retrograde ejaculation.
1. Semen analysis: Two samples after 2 to 5 days of abstinence, assessing count, motility, morphology and volume. This is the cornerstone of the entire evaluation.
2. Clinical examination: Testicular size and consistency, presence of the vas deferens and detection of a varicocele.
3. Hormone profile: FSH, LH, total testosterone and prolactin.
4. Scrotal Doppler ultrasound: Confirms varicocele and assesses testicular architecture.
5. Genetic testing: Karyotype and Y-microdeletion studies in severe oligospermia or azoospermia.
6. Sperm DNA fragmentation: Considered in recurrent IVF failure or recurrent miscarriage.
Both partners should be evaluated together after twelve months of trying, or after six months if the female partner is over 35. Come earlier if there is a history of undescended testes, mumps after puberty, testicular surgery or injury, chemotherapy, anabolic steroid use, or if you have noticed a varicocele or small testes.
1. Varicocele repair: Microsurgical or laparoscopic ligation improves semen parameters in a majority of appropriately selected men.
2. Hormonal therapy: hCG, hMG or clomiphene for secondary hypogonadism. Plain testosterone is avoided as it suppresses sperm production.
3. Treating infection and obstruction: Antibiotics for active infection, and microsurgical reconstruction for obstructive azoospermia.
4. Lifestyle correction: Stopping smoking and steroids, weight reduction, avoiding heat exposure, and antioxidant supplementation, typically over a 3-month cycle since sperm take about 74 days to mature.
5. Assisted reproduction: IUI, IVF or ICSI, with surgical sperm retrieval (TESA or micro-TESE) where no sperm are present in the ejaculate.
Time works against both partners. An untreated varicocele causes progressive testicular damage that becomes less reversible the longer it is left, and female fertility declines sharply after 35, so delay on the male side eats into the couple’s shared window. Many men spend years on unsupervised tonics and internet remedies before a single semen analysis identifies a correctable cause. Getting evaluated early costs little and often shortens the journey dramatically.

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